A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data.
One issue that does not appear to be addressed is opening attachments in Outlook. That is a bad practice. If you make any changes to the file, they will be saved in your temp folder, rather than where you expect. You should always download attachments before opening them.
You questioned the use of Safe mode. Safe mode in Office applications, like Excel, blocks the start of ALL addins. Addins have a long tradition of causing seemingly random problems in Office applications. There is also a Windows Safe mode that limits the Windows processes started. One of them is required for Office 365 applications.
Note: if you have Office 365, after you start Windows you will probably have to manually start the “Microsoft Office Click-To-Run Service”. You will have to start Services.MSC using RUN AS ADMIN.
Personally, my need is reverse of yours. I need/want to start Office applications in separate processes. My problem has been when I open too many files in the same process and one of them locks up, I lost unsaved changes in all of the files. As they say, YMMV ...
I have not encountered the issue of files being opened in separate processess. Is it possible that this is an automated "feature" that is invoked when the files require too many Windows resources, specifically RAM, Windows automagically starts a new process? Open Task Manager, make note of the RAM in use as you open the files one at a time.
I do not recall seeing explicit mention of which "bit" version of Office you have installed. The default is 32-Bit. You could try installing 64-bit. It allows the applications to use more of the available RAM for a single process. Most current PCs have 64bit Windows installed.
@ RAM Support increased 32bit Excel 2013-2016https://www.excelguru.ca/blog/2016/05/10/32-bit-excel-memory-limit-increase/****Excel 2016 build 16.0.6**** ways to boot into Windows 10 Safe Mode
https://www.digitalcitizen.life/4-ways-boot-safe-mode-windows-10