Same issue here. I thought I was going crazy. As soon as I stop playing a song/video, just a minute later my Bose USB-connected speakers turn off thinking the PC is off. I need to manually re-enable them before every attempt at playing music/any sound. I'm afraid my sound system will die on me from so many attempts at restarting it.
I've discovered (an unsustainable) workaround in constantly playing a long mp3 file on repeat that produces no sound. It prevents the system from shutting down my speakers, albeit it's annoying and unnecessarily wastes resources.
I keep on reading about 24H2 being very messy, but because of how significant this issue is, I really hope it's prioritized for addressing. I'm concerned as I've just gotten the 24H2 update, but this issue was first reported last year (!), and is seemingly still an issue.
The latest update did not address the underlying cause (Windows putting USB speakers into stand-by if no sound is playing, and it permanently shuts down many such speaker sets that do not re-engage when PC tries to make them play sound again. Needing to be manually turned on first, which is extremely frustrating).