Thank you Greg. It looks like the pages are not printed anymore. Before that change, i was able to reproduce the issue every time when I restarted the Print Spooler service.
One problem is gone, but there is still the issue, that windows has problems identifying the printers when they are attached to the computer.
If the USB printer is connected and I restart the Print Spooler service, it takes forever to list the installed printers.
If I detach the USB printer, the other printers are listed right away after Print Spooler restart.
MS tried to fix some issues with the KB5051989 (contains also KB5050092 - [USB Print and IPP Over USB] Fixed: An installed printer fails when the spooler initializes.) and made it even worst. If I uninstall this cumulative update, the system just works fine again.