TURN OFF BROWSER "hardware acceleration when available" - especially for systems with larges amount of RAM.
I have two windows 10 computers with almost identical specs (both of 64Gb RAM). One is a laptop the other a mini desktop. the laptop works great, and the browsers are all normal and responsive. But on the mini, ALL the browsers are slow - slow to open, slow to load pages, even after open, button clicks are slow to respond. Often, something is gets hung and you see the "(not responding)" appear near/in the url address bar.
Side by side, I would open the same websites on both systems...test on chrome and test on edge. The laptop opens immediately while on the mini it could take 10 to 15 seconds for the page to open.
I disabled all extensions and removed any and all software that could be impacting the mini's browsers. No change.
I compared all browser settings on the laptop to those on the mini....EVERYTHING was identical except ONE setting. On the laptop under "Advanced/System" settings, the "Use hardware acceleration when available" was turned off, but on the mini it was turned on.
I turned that off on the mini, on both Chrome and Edge - and at the moment it seems to have fixed ALL of by browser headaches. I will post back if I observe any more problems. But that one setting, assuming it is final fix, on the Mini has caused me fits for months.