Tim, here is a checklist of various things you can try.
1- Make sure you have the latest Win 10 updates after the 1806 update. Later updates may help with this issue.
2- Uninstall the Epson driver you have and reinstall the latest ones from the Epson Website that are suitable for Win 10. If there isn't one for Win 10 then try the nearest one (eg Win 8) If your software has an update driver feature that may help as well.
3- When launching Epson scan right click and select run as administrator.
4- You could also try running Epson scan in Win 7 or Win 8 compatibility mode. If that fails, switch it back to Win 10 mode.
4- Try the fix suggested by jonno_123, this involves a registry hack
http://www.geekstogo.com/forum/topic/291186-epson-scan-utility-wont-work/#entry2329211
If all else fails, you will probably still be able to use your scanner using the native Windows WIA feature. Its very limited but it should work. You can also try the Vuescan scanner driver ($).
Kind regards
Chris