Miscellaneous topics that do not fit into specific categories.
Hi claire,
Thank you for posting in the Microsoft Q&A forum.
Since this was working recently and the error message indicates that the server is unavailable, it is possible that this is a temporary service or connectivity issue rather than a problem with your Outlook profile. Recreating the profile and signing out/in would typically address common client-side issues.
For now, I would suggest waiting a day or two and then testing again. In the meantime, please check whether you can configure Automatic Replies through Outlook on the web (OWA). If OWA works while Outlook continues to show the error, that would help narrow the issue down to the Outlook client.
If the issue persists after a few days, please let us know whether it affects a single user or multiple users and whether you are able to set Automatic Replies in OWA.