A family of Microsoft relational database management systems designed for ease of use.
I applied the registry "FIX" to about 6 Windows 10 workstations. 1/2 the group had the access db corruption problem, the other 1/2 didn't. I only applied the fix to the workstations that needed it. We have had no problems with network connectivity or network drive mappings as a result of the "FIX".
I did not apply the registry hack to the server that the database lives on - only client machines. That might be what messed things up for you? I could easily see messing with network settings on a file server causing major problems.
Are you talking about the Disable Leasing fix or the other one?
Microsoft has just updated their status on this issue and now they are saying it only needs to be applied on the server hosting the back end.
However, in my experience doing this, I lost network drives and computers could not contact the domain (the server hosting the back end is also our DC, maybe that's the issue?). All workstations on the network were affected regardless of having the fix applied or not.