When starting Outlook "loading profile" hangs indefinitely

Press WinKey+R.  In the Open field, type regedit and hit Enter

Delete the following key to delete profile, once deleted re-create the profile.

HKEY_CURRENT_USER\Software\Microsoft\Windows NT\ CurrentVersion\Windows

Messaging Subsystem\ Profiles

Try

Press WinKey+R.  In the Open field, type

outlook.exe /resetnavpane

Be sure to include the space.  Press Enter.

If this answer solves your problem, please check, Mark as Answered. If this answer helps, please click the Vote as Helpful button. Cheers Shane Devenshire

Outlook will not start in safe mode either.  Tried repairing office.  Can't even delete a profile as that hangs as well.

I've seen this problem several times and it's not tough to fix.

Rather than deleting a profile or taking any other destructive approach, I've found that you can simply create a new one with no risk.

Step One: Make sure Outlook is not running:

• CTRL-ALT-DEL to open the Task Manager.
• Choose the "Processes" tab to show all running processes.
• Right Click on Outlook.exe (if it is running) and select "End Process Tree".

Step Two: Back up your profile:

• Go to Control Panel/Mail and choose "Show Profiles..." to open the profiles dialog.
• Rename your broken profile to "old profile"
• Select "Prompt for a profile to be used".

Step Three: Start Outlook - problem solved:

• Now start Outlook normally.
• When it asks which profile to use, click on the "New..." button.

Outlook will now simply create a completely new profile which will, hopefully, solve all of your problems.

Once you have finished this troubleshooting/repair, tell Outlook to always use your new profile (See Step Two for instructions).