Using older versions of Outlook for Mac for personal email and calendar
I just took our (Pensacola State College) 2016 iMac to an Apple authorized service center for the display flickering issue. They replaced the hard drive AND display. Still having the same issue. Obviously not a defective display or OS issue. We are checking into the Skype theory.
I checked/set the "Low Resolution" option in Outlook on our iMac that some recommended here and more than 2 days later the issue has not returned.
I also had an issue with Outlook menus and sidebars going black intermittently on my Windows 10 PC using Outlook 2016 and even after I upgraded to 365. The menus and sidebars would go black after a few minutes (never actually timed it) of inactivity. All I had to do to bring them back was click anywhere inside the window. I checked/set the "Disable hardware graphics acceleration" in the Outlook Options and that seems to have resolved this issue also.