Here is what worked for me.
Step 1. Uninstall all Epson software by using the Control Panel Programs and Features uninstall process.
Step 2. Download ALL Epson files related to my scanner from the official Epson Perfection support page. Here is the link.
https://epson.com/Support/Scanners/Perfection-Series/sh/s210
I selected my scanner model from the list, which took me to the scanner’s support page.
From the dropdown list I selected Windows 11 as my operating system – even though the web form “detected” Windows 10 64 bit. Make sure to hit the “GO” button to reveal the list of downloadable files.
Step 3. There were seven files displayed under the “Utilities” section. I downloaded all of them into a file folder on my hard drive – noting the date of each file.
Step 4. Rename to add numbers to all files according to their associated date, starting with the oldest first. My renamed files looked like this:
1_epson16827.exe – Epson Copy Utility v4.1.1+
2_EPS_1.00.10.exe – Easy Photo Scan v1.00.10+
3_V550_EScan_3923_AM.exe – Scanner Driver and EPSON Scan Utility v3.9.2.3+
4_ESCU_1.0.0.0.exe – Common Updater for Epson Scan v1.0.0.0+
5_EEM_31153.exe – Epson Event Manager v3.11.53+
6_ESCU_W11.exe – Epson Scan Common Updater v1.0.0+
7_ESU_4.6.3.exe – Epson Software Updater v4.6.3
Step 5. Install all seven files sequentially, starting with 1_epson16827.exe and working methodically up to 7_ESU_4.6.3.exe
Step 6. Turn on scanner. Reboot.
Everyday operation (after performing this reinstall)
Step 1. Turn on scanner and then boot. Make sure scanner is powered on before boot.
If Windows is running but the scanner was not turned on before boot -- and if the scanner is not responsive do the following:
Step 1. Turn on scanner.
Step 2. In Windows 11, run services.msc. Find the “Windows Image Acquisition” service. Restart that service. Agree to restart Epson scanning service.
Step 3. Run Epson Scan. This should initialize all necessary electronic connections. Might need to run once, close, and run a second time.
Anyways, this is what is working for me… today. I hope it works for me tomorrow as well.