I have been trying a number of things to solve this issue. My hunch is that the lag/jitter has something to do with applications or the OS trying to communicate with the internet and when there is not enough priority, or sufficient throughput and it gets into a brief wait state. Unfortunately, there are so many variables, that it is not a straightforward task to identify. It could be in the software, OS, drivers, motherboard, or possibly the interrupt handlers at the CPU level. I haven't been able to track down any specific or repeatable actions that narrow the list down with any confidence. It doesn't help either that it is intermittent.
One thing I did notice was that Edge and any subsystem which used it (i.e. Win11 Widgets), was fairly resource intensive and seemed to be hitting the internet frequently. Not that Edge itself is the root cause, but I ended up uninstalling it completely and went to a more lightweight browser and at nearly the same timeframe, I also changed my ISP to a faster provider (I went from 10Mbps DSL to Starlink).
What clued me in on this hypothesis was that Starlink occasionally has dropouts where the satellites are obstructed, and I have seen the mouse stutter in close proximity to those internet outages.
Since then, I have not seen the lag (outside of outages), or at least not to the the degree where it is frustrating.
Is it Edge, is it internet speed, is it background processes like Windows Updates accessing the internet and getting held up? I don't really know for sure, but it *feels* like they are interrelated with networking.
For those of you who experience the jitters frequently, I would be curious if you could find a time to work completely offline for a duration of time that it would likely happen (disabling all networks) and see if the problem goes away. If it does, but then it returns after re-enabling wifi/ethernet, then we may have some good leads into tracking this problem down.