I got to this thread as I was having issues with popping suddenly on my Edifier MR4 Speakers/Monitors.
I use an M-Audio M-Track Solo connected via USB to my PC, and the speakers are connected through this device.
I was having some popping that I thought was coming from my browser, as activity in Chrome seemed to cause the most constant popping even when no sound was being played. I messed with everything - drivers, cables, Fast Start... Nothing helped.
...and then, quite by accident, I just turned the Output volume down on the M-Track, from ~9 to ~5, and increased the volume out from the PC - so essentially had the same volume coming from the speakers, and the popping vanished 😂
I mention this as others here also mentioned an M-Audio device.