Modern replacements may be possible, but it would be a extensive project to verify they would work (if they even did). Of course, at some point, one has to address the long term viability, but some transition time would be nice (and be able to observe behavior of the original).
No other hardware was touched. I think the exact process was that I removed the OS drive and tried booting (I wasn't sure which was which). It just didn't do anything as expected. Then I put the OS drive back in (realizing which was which now) and also put the new drive in (but skipping the step of verifying that everything would work if I put it back together as before - just assuming it would). At this point, when I booted, it had an issue and automatically tried to fix it. I was able to get to the repair screen (from the OS drive), but none of the basic options did much. I put everything back together as was before, but same issue of not booting (straight to repair options). Then I hit the forum because I am not familiar with Win10 recovery. I was quite good at DOS, 3.1, W95, W98, W2000. After that, my skills dropped off.
As far as the BIOS "setup", its a typical kind of BIOS from 2010 (ASUS). I don't think I really adjusted anything from the defaults (maybe a few minor things).