I found another setting that directly effects sound output. In addition to the Windows enabled enhancements, the Realtek Audio changes and the SS3 Advanced mode Sonic Studio Effects to On and Basic Mode Sonic Studio Effects.
All the settings changes in the Realtek Audio and SS3 will stick, even the Upmix option. This is on a basic 5.1 speaker system.
On the ASUS site, there are instructions on how to remove and install the drivers. This is in the community forums and the one here for the 670 and 790 boards has quite a bit of info as to sound components. He is also one of the primary ASUS folks that helps set up drivers.
[DRIVERS] Realtek USB Audio (Intel 5xx/6xx/7xx & A... - Republic of Gamers Forum - 845528 (asus.com)