I have been having the same problem with Windows 11 since June of last year. SO frustrating. My main issues occur while streaming music like Spotify, then when I execute other processes like loading a script heavy web page, or opening other programs - the sound will pause and then be delayed, or it will skip and start crackling like CRAZY, with lots of distortion.
The only way I can fix it is to unplug the interface, and plug it back in. I do this probably 10 times a day because I'm a voice teacher and use my computer audio all the time.
The audio has no issues playing from my computer, or over 3.5 aux port. This is a USB issue with Windows 11. I think the power is occasionally lowered or is dropped for the USB ports for power management, and it wreaks havoc.
I've installed the latest Focusrite drivers multiple times, told the system to optimize background processes, turned off power saving in the control panel for every USB device in the list, stopped getting Windows Insider Preview builds, nothing has fixed this.
MICROSOFT PLEASE FIX YOUR USB ISSUES IN WINDOWS 11!
My System:
Device name Cameron-M16
Processor 12th Gen Intel(R) Core(TM) i7-12700H 2.30 GHz
Installed RAM 16.0 GB (15.7 GB usable)
Device ID 6C4BCACE-51EA-48E6-BDA0-A1E525C6FEE9
Product ID 00342-20785-25419-AAOEM
System type 64-bit operating system, x64-based processor
Edition Windows 11 Home
Version 22H2
Installed on 8/18/2022
OS build 22622.575
Experience Windows Feature Experience Pack 1000.22634.1000.0