1. Limit FPS to 120FPS via Nvidia control panel
2. set power management to "adaptive" in Nvidia control panel
3. Usw MSI Afterburner and add a flat -50MHz to VRAM, and lower power limit to 80%
~~One note though, I don't have the "adaptive" power management option on the Nvidia control panel, but that might have something to do with me using Studio drivers instead of Game drivers.~~
~~Many thanks to the @mkxy~~
Even though I appreciated the input striken above, which improved a bit the reliability, in the end it didn't work.
After two entire days (didn't happen for a few months now), I can say that I have no freezing issues anymore, without using Afterburner.
The only setting which made a difference on my MSI Ventus 4070 Ti 3X 12G OC (read in the nVidia forums) is to change "**Power Management**" to "**maximum performance**".
https://nvidia.custhelp.com/app/answers/detail/a\_id/3130/~/setting-power-management-mode-from-adaptive-to-maximum-performance
Again, this is for very low GPU loads, just for using the computer I had lockups. Hope it helps someone.
I don't have any other specific settings applied other than using PCIe gen3 instead of gen4 which was impossible to use with my Asus B550-i.
**Edit**: even considering the improvements above, I still had issues with the board. I ended up removing it and reseating it with as best care possible, and that resolved the issue (no issues for months now).