Likewise, I purchased a new computer. It came with .NET Framework already installed. I received the same error as Deborah when attempting to use two different programs, Neuro-programmer3 and Mind Workstation, which worked on my old computer. I was waiting
and hoping for an update from Microsoft to fix the problem with the .NET Framework. I was growing impatient and did more research. I ran across Deborah's posting describing the same error running Neuro-programmer 3.exe.
My older computer was still able to run the 2 programs without the .NET Framework error and program crash. I manually ran Windows Update on my older computer and now these two programs will no longer run after updating Windows. Now I get the previously specified
error and program crash on my older computer too. A change has apparently been made to the .NET Framework in a 2018 Windows update which now results in these two programs crashing with the error message specified by Deborah.
I had found references to the same error message mentioned by other Windows 10 users on several forums while I was searching for a solution to my own dilemma. I hope that Microsoft is able to resolve this issue.
If anyone is currently able to run Mind Workstation or Neuroprogrammer 3, I would appreciate your input as to any measures that you might have taken to circumvent this problem.