@Mudnail
I can confirm leaving Outlook 365 closed did help, it took longer for Task Manager to start acting crazy and slowing down the computer down. I was able to actually close it to restore full use of the computer when it started. (It took about 10-20 minutes before the computer started to hiccup with it open.) So it's a good start....but not perfect in my testing.
Fingers crossed that RS4, whatever it ends up being called has a hidden fix that addresses this as obviously Microsoft isn't helping.