Like Emily, I don't have Skype or Firefox running. I tried other solutions I found online:
- Increase the size of the paging file
- Disable SuperFetch and Windows Search in Services
- Disable Prefetch in the registry
Nothing worked.
I moved the paging file to my non-system drive, and I increased its size to about 5x the recommended size. Disk usage on the system drive is now in low single digits when I haven't asked the computer to do something, and the drive with the paging file looks totally bored. My machine is back to its awesome former state.