It doesn't work in my case as I don't use Chrome and Skype.
It is easy to fix the hard drive usage at 100% in Windows 10: install an appropriate chipset / SATA driver.
I had an AMD A10 system with 16GB of ram, discrete graphics, SSD for boots and HDD for data. The harddisk usage is often at 100% and slowing down my system.
I downloaded the AMD chipset driver, and installed it. However it does not install the proper SATA controller driver. So it is still at 100%.
Then I fix it manually in Device Manager, double click your standard SATA controller and press update driver. Then when installing manually, navigate to the driver on the temporary directory created by AMD chipset installer. Windows will update the driver and never again using my SSD at 100%.
The applies to Intel system as well. If you cannot find Windows 10 driver for Intel chipset, installing Windows 7 driver will do just fine for my Intel 945 and Intel H55M chipset.