http://www.microsoft.com/security/pc-security/windows8.aspx
On Windows 8 when a third party antimalware program is installed the Windows Defender (WD) program is disabled.
If you wish to use WD on W8 you must uninstall the third party antimalware program, run the McAfee Removal Tool, Norton Removal Tool, etc and reboot the computer. List of anti-malware product removal tools
WD should then be enabled though you may need to start the program in Security Services.
For further information see
http://www.eightforums.com/tutorials/21962-windows-defender-turn-off-windows-8-a.html
Windows Defender on Windows 8 - Introduction and Frequently Asked Questions