Interesting stuff...
I'm don't think desktop Skype can be the only culprit, sadly, as I didn't have it installed until very recently (yet still saw the xHCI controller issue). That said, I do have VoIP phone software installed - I wonder whether there could be some interaction with the camera and/or headset which is causing the problem.
I'm wary of going down the refresh route (not least as this is a corporate PC, reinstalled with Windows Enterprise so I'm not even sure if a refresh is possible). It'll be interesting if your probably comes back or goes away, though.
FWIW - before I left work on Friday, I rebooted the machine and then put it straight into sleep (after, admittedly, both Skype and my VoIP app had started). I lost only 10% over the weekend (but, again, the culrprit was the xHCI controller running for 100% of the sleep time).
I'll try again tonight, but without starting the VoIP app, or Skype.