A couple of things to report. I just tested my wife's Surface Pro 3 with i5 processor, and again the Skype was the culprit, she had USB xHCI Compliant Host Controller (\_SB.PCI0.XHC) active 100% of time during sleep and battery got drained 11% during 4 hour sleep. After quitting Skype, 0%.
Another thing is that with recent update, I cannot do sleepstudy with powercfg anymore - I'm not sure what is going on. It says The Power Efficiency Diagnostic library (energy.dll) could not be loaded when I do > powercfg sleepstudy.
As you say, it looks like Skype (or, I think, more generally, comms apps which perhaps use the headset of camera - remember, I was seeing this xHCI problem before I'd even installed Skype) are the killers.
So, is this something which MS needs to address in the Surface drivers, or is it something application writers need to fix (which, of course, in Skype's case, is MS!)? Either way, how do we draw more attention to it, so that someone with power to fix it takes an interest?
FWIW - I can still do a sleepstudy (and believe I'm up to date with updates).