Using classic Outlook for Windows in business environments
In short - there's no way to use GPO to set up email signatures in the new Outlook. And if you're using VBScript, there are plans to deprecate it soon, so it won't be possible to use it for the classic Outlook either. There are alternatives, though.
You can use PowerShell to add email signatures to users' mailboxes. Set-MailboxMessageConfiguration , to be precise. Here is a walkthrough for the process . Mind it might not work with the "roaming signatures" aka "signature cloud settings" turned on. And, like @SokiGuo-MSFT mentioned, you can use mail flow rules to add disclaimers. The process is even easier if you use a dedicated signature generator, which lets you get HTML code ready to paste into Exchange admin center. This video includes a step-by-step guide.
Those methods are completely free to use, but have some limitations. Other alternatives require third-party signature management tools.