Hi Matt,If the two Excel files were added to the agent as knowledge sources, the agent is primarily using them to retrieve and reference information; adding a file as knowledge does not by itself give the agent the ability to edit the original workbook. Microsoft distinguishes knowledge sources from connector-based actions/tools that can perform operations.
If you need the agent to update an editable workbook, store the workbook in OneDrive or SharePoint and configure an appropriate action/Power Automate flow with write permissions rather than relying only on the Excel file as knowledge. Also confirm that your account has Edit permission on the destination file and library.
If the duplicate itself opens as read-only even outside Copilot, check its SharePoint/OneDrive permissions and library settings, as these can also cause Office files to open read-only.
Thank you, and feel free to respond back for more assistance.