copy and past is not happening in Microsoft excel 2016

This is a known issue due to a recent update. See article https://support.microsoft.com/en-us/servicing/office/hotfix/excel/5002914

Please type cmd in the search on the taskbar. Don't press enter key yet. Instead, choose "run as administrator" to launch Command Prompt. Run the command accordingly to roll your Office back to the last stable version.

Then run this command (for Office 2016 retail MSI installer)

"C:\Program Files\Common Files\Microsoft Shared\OFFICE16\Oarpmany.exe" /removereleaseinpatch "{90160000-0012-0000-1000-0000000FF1CE}" "{27882596-A8ED-4382-9C71-6CD2DD19F732}" "1033" "0"

For Office 2016 Retail Click-to-Run, use this instead

"C:\Program Files\Common Files\Microsoft Shared\ClickToRun\OfficeC2RClient.exe" /update user updatetoversion=16.0.19127.20264

Hi @Amitava Pradhan

Please note that Microsoft Office 2016 reached End of Support on October 14, 2025. After this date, Microsoft no longer provides security updates, bug fixes, technical support, or time zone updates for this product.

Based on the information you provided, I understand that after installing KB5002914 for Excel 2016, copy and paste operations using either the keyboard or mouse are no longer working, and AutoFill functionality for numbers and formulas has also stopped functioning correctly.

After doing some research, I found that several other users have reported very similar symptoms after installing KB5002914, so it does not appear that you're the only one affected. There are currently community discussions where users experiencing the same issue have shared temporary workarounds and troubleshooting steps.

Ref: https://learn.microsoft.com/en-us/answers/questions/5998543/issue-with-excel-2016-copy-and-paste-cells?comment=question&translated=false&page=1#answers

In the meantime, while waiting for an official update or resolution from Microsoft, you may want to review the following Microsoft article and consider rolling back to a previous Office build if the issue is significantly impacting your work:

Description of the security update for Excel 2016: September 08, 2026 (KB5002914)

Based on the reports from other affected users, reverting to the version prior to KB5002914 has helped restore normal copy/paste and AutoFill behavior in some environments. However, because rolling back an update can have security implications, it's generally recommended to coordinate with your IT administrator before proceeding.

Could you also confirm whether your Office installation is MSI-based or Click-to-Run? The rollback process is different for each installation type.

Please keep me updated with your findings.