Hi, good day!
Since you've been able to reproduce the issue on two different dual-monitor setups and confirmed that uninstalling KB5100998 resolves it, I recommend submitting feedback through the Feedback Hub app to notify the Windows engineering team. When submitting your feedback, include the update number (KB5100998), describe the monitor behavior, and mention that the issue affects multiple PCs but is resolved after uninstalling the update. If possible, attach screenshots or a short video demonstrating the issue.
In the meantime, you may want to temporarily pause Windows Updates to prevent KB5100998 from being automatically reinstalled while the issue is being investigated. Once a fix or a revised update becomes available, you can resume updates to keep your device protected and up to date.