Hi Andy Cannon,
Based on the symptoms and the troubleshooting already completed, this does not look like a Paint-specific issue. The key indicator is that multiple Microsoft Store/packaged applications (Paint, Notepad, Outlook, and CrossDeviceResume) are all failing with the same "Interface not registered" error on multiple Windows 11 devices.
You may try some suggestions bellow:
- Test with a New User Profile
Create a local test account and verify whether the affected apps launch there. If they do, the problem may be isolated to the user profile rather than the operating system itself. - Perform an In-Place Repair / Reinstall of the Current Windows Version
Reinstall the current version of Windows following this article: Fix issues by reinstalling the current version of Windows. - Uninstall Recent Windows Updates
Since the issue reportedly began across multiple machines in early July, I would review installed updates and test removing the most recently installed cumulative update on an affected machine to determine whether the problem was introduced by a specific update.
If you have further information, please feel free to let me know.