Hello Patel,
Since gpresult is reporting Access Denied when accessing SYSVOL, I would focus on the ACL/replication hypothesis first, not the ADMX version mismatch.
A corrupted or unsupported ADMX/ADML file typically causes Group Policy processing or GPMC display errors, but it does not normally generate SYSVOL access-denied errors. If clients cannot read files from \\<domain>\SYSVOL, verify SYSVOL and NETLOGON accessibility, compare permissions across all DCs, and check DFSR/replication health using:
dcdiag /test:sysvolcheck /test:advertising
dfsrdiag backlog
repadmin /replsummary
Also confirm affected machines can access:
\domain.com\SYSVOL
\domain.com\NETLOGON
without authentication prompts.
Given the issue started immediately after a Central Store update and affects ~500 machines in a single OU, my leading suspicion is that the ADMX update inadvertently changed permissions on a Central Store folder or that SYSVOL replication propagated incorrect ACLs to one or more domain controllers. I would validate SYSVOL ACL consistency and replication health before investigating ADMX schema compatibility.