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Thank you for the additional information. The error message [0x80070005-0x000004dc-0x00000524] usually indicates that "This message could not be sent. You do not have the permission to send the message on behalf of the specified user."
I understand that sending works as expected in webmail using the “send as” option, and the issue only occurs in Outlook on Windows.
To better understand your situation, may I kindly ask for some clarification:
1/ Could you please describe how the mailer was created? For example, is it an alias or a shared mailbox, and how was the “send as” permission assigned?
Also, does this mailer appear in your organization in the Microsoft Admin Center?
2/ Could you confirm which version of Outlook is being used, Classic Outlook or the new Outlook?
3/ Would you be able to share a screenshot of the issue through private message?
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If I’ve misunderstood any part of your situation, or if you have further questions or updates, please don’t hesitate to reply.
Thank you for your time, and I look forward to hearing from you soon.
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