A family of Microsoft word processing software products for creating web, email, and print documents.
AFAIK, newer versions of Word for Mac use a stricter “math autocorrection” and equation parsing engine than older builds did. In current Word 16.x releases, a single plain-text character is often treated as ordinary text unless Word can clearly identify it as mathematical content. Effectively, pressing Control+= on a highlighted single letter no longer automatically converts it into an italicized math variable the way older Mac versions did.
First, make sure you are actually inserting a true equation object and not just applying formatting. In Word for Mac, the default shortcut is usually Option+= to insert an equation, while Control+= is normally subscript. If your old setup used a custom shortcut or older behavior, the migration to the new Mac and Word version may have reset it.
You can improve the behavior by enabling Math AutoCorrect inside equations. In Word, preferences, enable “Replace text as you type” and “Use Math AutoCorrect rules outside of math regions.” This should restore some older equation-entry behavior.
Alternatively, insert the equation first using Insert > Equation (or Option+=), then type the variable directly inside the equation box rather than converting existing text. If the letter still appears upright, force Word to reinterpret it as math by typing a space after it, adding a superscript/subscript briefly, or typing something like x+1 and deleting the extra part afterward.
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hth
Marcin