Macros that we wrote in Project Online in the Enterprise Global template are now disabled with the latest office upgrade.

Dear Sunil Nadig,

Good day! Thank you for posting to Microsoft Community. We are happy to help you.

As per your description, it seems that you are having issue with Project Online, Macros get disabled with the latest office upgrade.

If the understanding above is right, to help you better and for the further troubleshoot, we would like to collect more detailed information you're experiencing so that we can have a further investigation:

1. Would you please share screenshots of the issue encounter again by using the Insert image button (as shown below), or directly copy and paste the image to your post.
2. Does the issue happen on different devices with different users?
3. Please also share your Office version with us by going to Project Online desktop app > File > Account and take a screenshot as shown below? For your reference: What version of Office am I using? - Microsoft Support

Meanwhile, please check the suggestions shared in below official article can help.

For your reference: Enable or disable macros in Microsoft 365 files - Microsoft Support

Appreciate your understanding that sometimes the initial reply may not resolve the situation very soon. However, we can work together to narrow down and resolve the situation. Please kindly post back and provide the more information, then we can focus on your specific scenario and provide specific suggestions.

If the understanding above is not consistent with yours, please feel free to post back and point that.

Your understanding and patience will be highly appreciated. We hope that you are keeping safe and well!

Thanks for your cooperation.

Sincerely，

Rhoda | Microsoft Community Moderator

I am having the same issue.

Answers to your questions below:

1. Would you please share screenshots of the issue encounter again by using the Insert image button (as shown below), or directly copy and paste the image to your post. --> The Insert image option is not working properly, it fails every attempt to upload an image. However, the error message is very clear saying: Microsoft Project Security Notice Microsoft Office has identified a potential security concern. Microsoft has blocked macros from running because the source of this file is untrusted. File Path: global Microsoft has blocked macros from running because the source of this file is untrusted. [More information] [Disable Macros]
2. Does the issue happen on different devices with different users? --> Yes, it is happening to other users on different devices.
3. Please also share your Office version with us by going to Project Online desktop app > File > Account and take a screenshot as shown below? --> The Insert image option is not working properly, it fails every attempt to upload an image. However, the error message is very clear saying:

Subscription Product for xxxxxxxxx@xxxxxxxx
Microsoft Project Online Desktop Client

This product contains

[Project icon]
Manage Account Switch License Update License

Microsoft 365 and Office Updates
Updates are automatically downloaded and installed.

[Update Options icon]
Update Options ▼

About Project
Learn more about Project, Support, Product ID, and Copyright information.
Version 2407 (Build 17830.20166 Click-to-Run)
Current Channel

Finally, the suggested solutions on the link shared does not solved the problem.

Regards

Dear Juan Videla,

Thanks for posting back.

Considering that different users are encountering a similar situation with different tenant, the suggestions shared in the official article cannot help, more resources need to be involved in to help you further. In this situation, for work/school account organized by the organization, we'd sincerely recommend you contact your Microsoft 365 administrator, follow steps in this article to create a support ticket with Online Support. The support team over there has higher permission than us, they can remotely help check the situation on your side, involve more resource to collect logs and help you do troubleshoot. This would be a more efficient way in handling this case for you.

For reference: How do I find my Microsoft 365 admin?

Meanwhile, please also send feedback about the behavior via File>Feedback or Help>Feedback within Project. Feedback submit by this way directly goes to the related team, this is the best way to let Project developers aware of this situation, help do investigation for the issue and fix it soon.

For your reference: How do I give feedback on Microsoft 365? - Microsoft Support

Best Regards,

Rhoda