A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data
I was getting extremely slow screen updates. When I move my mouse the buttons and other UI elements would only highlight about once per second. Every time I move the mouse and click I had to wait about five seconds for the display to catch up.
For me, selecting Optimize for compatibility did not solve the problem. But because it was a display update issue I tried disabling the GPU and that solved it!
File > Options > Advanced > Display > Disable hardware graphics acceleration.
Restarting Excel afterward was not required. It immediately started working right.
This is in Office 2016, but I believe the setting is the same in Office 365.
My GPU is an Intel UHD Graphics in a new Dell XPS 17 running Windows 11. It's a very high-end machine to be giving such a crappy experience.