A family of Microsoft relational database management systems designed for ease of use.
These settings fixed the 'Error 3048: Cannot open any more databases' bug for me:
ACCESS SETTINGS
Access > Options > Trust Center > Trusted Locations > Trust Center settings > Trusted locations > Access folder location(s)
WINDOWS SETTINGS
Settings > Windows security > Virus & threat protection > Manage settings > Real time protection > Off
Settings > Windows security > Virus & threat protection > Manage settings > Exclusions > Add or remove exclusions > Access folder location(s)
NB. Access > Trusted Locations is not enough to stop this bug, these Windows settings must be used as well.