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Also: does anyone know if it would be possible to "manually" set up the profile, via registry editing, etc.?
it needs too many keys to do it in the registry. if you previously had outlook set up on the computer, the account should migrate over to outlook 2016, however several people said it didn't work for them.
You can try using an xml file.
Files are here: C:\Program Files\Microsoft Office\root\Office16\OutlookAutoDiscover
See
https://technet.microsoft.com/en-us/library/cc511507(v=office.14).aspx for ore information.