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>> When I hit ok "Cannot Start MS Outlook. Cannot open the outlook windows. The set of folders cannot be opened. The information store cannot be opened".
This is because the account can't find the server so it can't create the ost or connect in online mode.
>> If i do change account settings, and try Outlook.com or ExchangeActiveSync,
Exchange ActiveSync only works with outlook.com accounts, not with exchange server accounts.
>> (webmail.sc.edu) and domain name (DS); but in the Outlook 2016 Windows version it only asks for email address and mail server, not my domain name; and not my username on the domain.
Outlook 2016 Windows uses autodiscover to configure Exchange accounts - it finds the server names for you.
Do you know if the school runs their own servers or use Office 365? If they have their won servers, what version of Exchange?