A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data.
I have actually been in touch with Microsoft support about this issue, and they have got some way in finding the issue. It turns out to be a call to some Office interoperability DLL (I can't recall the name) that keeps timing out after a few seconds. They are still trying to find the particular function(s) in my spreadsheet that are triggering this call to the DLL, but I will try to remember to post a reply here once they find the offending function(s).