A family of Microsoft spreadsheet software with tools for analyzing, charting, and communicating data.
What do you mean by I can’t run Excel in safe mode for a while?
Excel would always work faster in application safe mode because it disables all add-in.
You can disable the add-in and check how it works.
You can change the default printer and check it fixes.
Here is the link to change the printer.
http://windows.microsoft.com/is-IS/windows7/Change-your-default-printer