Hi,
As I mentioned in an earlier post, I moved back to Pub2010 because I couldn't solve the unresponsiveness and slowness issues in 2013.
I have previously tried all the fixes in this thread and none of them have been satisfactory (IMO). I have also tried disabling 'page navigation' and this didn't work. Hiding pictures (Ribbon VIEW/'Graphics manager'/ bottom of new panel 'Change picture display'/'Hide
pictures') does make the document responsive, but it's arguable whether or not this is a fix, since you are removing a feature most people find integral for checking aesthetics and quality control.
As for compressing pictures before I have even settled on their correct arrangement in the document, I feel this contradicts the very notion of desktop/professional publishing. It may be acceptable when you are sure you will not be resizing images and only
need to export to one source, but I would normally treat image compression as a terminal procedure, in preparation for document export to one's chosen media/publisher. Also, as has been mentioned by others, one can work without compressed images in Pub2010.
However, for testing, I have just now copy and pasted a complex multi high-res image containing page from one of my active 2010 documents to pub2013. As expected this 2013 document was then very unresponsive. Incidentally, the images appeared down-sampled
in normal view at the same magnification in pub2013 compared to 2010 (see screen shot crops - didn't control crop size but both images are similarly scaled and magnified[150% in publisher]).

left
pub2010, right pub 2013. I have also tried pub 2010 with fast resize and zoom option on and I obtained the same result.
This is kind-of interesting considering publisher 2013 doesn't even offer a fast resize and zoom option for displayed images, but this is not the main topic of this reply.
I then took about 15 minutes manually selecting each image in the new pub2013 document and 'Saving as picture...', choosing .png and 300dpi. I then used the 'Graphics Manager' panel to replace each original image with the newly created 300dpi version. This
also made the document responsive. In fact this page may now be as-responsive, if not more so, than the original page in the pub2010 document. Therefore, some would consider this a fix. I personally prefer to know I have the original resolution image within
the document, so will continue to use pub2010. This method would also be quite time consuming, as an additional step or if one wants to modify/fix existing large documents, although there may be way to integrate the required steps into a new SOP when beginning
new documents so as to be less time intensive.
Kind regards,
Sponges...