Using Classic Outlook on Windows for personal email, calendar, and contact management
Yes... This renders Outlook practical useless. I sometimes have multiple emails opened to either multitask or cross share information between emails. When the Outlook screen gets scrambled, nothing is viewable, so the only thing is to shutdown and restart Outlook but then I risk lose all the data that's not saved or sent. The scrambling also impact the popup dialog asking if you want to save unsent/unsaved items, but I can't even make out the position of the button to click it, and hotkeys like Y or S don't seems to work in these cases.
You also nailed another key issue - MS spent so much efforts moving things around between updates that we didn't ask for, so we don't even have enough muscle memory to approximate where a button might be to blind navigate when the screen is scrambled like this.