HiChetan Akarte1
Greetings!
Thank you for posting in Microsoft Community.
Upon reading the description you have posted, it seems that you have an issue with Microsoft Office 365 wherein using your Excel app you want to know you can't access Python.
Let’s work together in finding the best solution to this issue.
For me to better understand the issue, I’d like to ask a few questions:
• What error message are you getting when you try launch python on your Excel program?
• What is the current version number and edition name of the Microsoft 365 program installed on your device? To check the build version and edition name. Just follow the steps provided from this support link: About Office: What version of Office am I using? - Microsoft Support > It should look like this : 
• What initial troubleshooting steps have you tried so far?
In the meantime, we would like you to provide us with some answers first to the questions above. In order for us to provide you with a more accurate solution.
We look forward to your reply,
Sincerely
Khou Sun
Microsoft Community Moderator