Been doing all of those things; nothing has had any noticeable effect.
I've done a clean startup, without anything starting automatically, and even then 40% memory is used just after startup.
Uninstalled all the software I could, played with the page file size up and down (windows had automatically set it to about 29gb).
It is a corporate machine, so some bloat exists, but nothing extreme in my opinion. I'm mostly confused about the 4gb that is missing from the Activity monitor, where do they go?