Wdcsam64.sys driver preventing me from turning on memory integrity

Use msinfo32 you can type it from the run command:
in the window select Software environment, then system drivers; it will tell you the path to the file your system is actively using:
wdc_sam WD SCSI Pass Thru driver c:\windows\system32\drivers\wdcsam64.sys Kernel Driver No Manual Stopped OK Normal No No
That is the typical information listed; since this driver is maintained by Western Digital and is incompatible with windows, Microsoft should not use this driver; then western digital would update it, one would think. Personally Windows 11 should just let you enable/disable the affecting driver right in the incompatible drivers security panel; and windows should carry any default drivers that disable important security features.

None of the posted workarounds resolved the Wdcsam64.sys conflict that prevented my Windows 11 system from turning on memory integrity.

Then I found a search result to install WD Discovery for Windows from this URL:

https://downloads.wdc.com/wdapp/Install_WD_Discovery_for_Windows.zip

After a couple of reboots I was able to enable Core Isolation features, and the the warning flag in the system tray went away.

As an added bonus, my USB drives now respond much more quickly when I attach or right-click to eject them.

Here's a link to a WD support page about this issue:

https://support-en.wd.com/app/answers/detailweb/a_id/49934

Uninstalling the WD SES driver, worked for me and my Passport drive still works fine.

It seems many people using WD external drives come across this problem. Plug and Play means the drive has files that it downloads to your computer first to get it to work properly. However, those files could be old, causing the problem.

Try going to this site (https://support-en.wd.com/app/products/downloads/softwaredownloads) and re-installing whatever software it downloaded to your computer (match the icons there to whichever icons are showing up on your desktop and download those). That worked for me a year ago.

googledegook is right.