I'm having a similar issue.
Yesterday I upgraded my TV to a Samsung 75" Q60C 4K.
I've got an Intel NUC attached to a receiver/amplifier which is then in turn connected to the TV. When I'm using the NUC, the screen randomly goes black for a second.
The screen only does it for the NUC and only when through the receiver. My PS5, also connected to the receiver does not have an issue and when I swap the HDMI cables each device works the same as before the swap. If I connect the NUC directly to an HDMI port on the TV it works without issue. I'm completely stumped and really don't want to have to stop using my NUC through the receiver.
A friend suggested something called the extended black function, but I haven't been able to find anything...
I tried the refresh rate idea and no joy...