OK so from a previous post here that but the location of this file BrUsbSlb.sys, I tried removing it from the directory and I didn't have permission, so I gave myself full access to this file and removed it from the directory and placed it on my desktop (just in case) and then back to the Core Isolation, turned it on and rebooted all good, sorted!
I tested my brother's 810w label printer and it still works.
recap I removed this file BrUsbSlb.sys, enabled Core Isolation and rebooted job done