I had the same problem. It seems it was stuck in "tablet mode" and I fixed it by closing and opening the laptop lid.
I recently upgraded to windows 11 on my laptop, and I can't disable item check boxes in the file explorer.
Disabling item check boxes works on the desktop, but not in the file explorer (see attached screenshot).
I have tried disabling "Use check boxes to select items" in folder settings, and changing the value of HKCU\SOFTWARE\Microsoft\Windows\CurrentVersion\Explorer\Advanced\AutoCheckSelect to 0 in the registry, both of which do not solve the problem.
Any help would be much appreciated :)