What do you think happens, that makes your pc better/faster/whatever, after "cleaning" the registry?
Genuinely curios now
Lets say you have 500 "dead" entries, thats like .. 41KB of data "wasted" ( i made a notepad with 500 lines of random text, about 100 chars on each line, which is a lot larger than a registry is, of course) on your harddrive, lets say that gets loaded into RAM for some reason, thats 41KB of RAM less. And you have hundreds of thousands of active entries.
How much does your Wise registry cleaner use?
Lets say 50MB of RAM on startup (assuming you have it on startup) and 250MB on your system drive (if you have it there), so the program by itself, so the solution is thousands of times worse than the problems its "solved".
Not to mention you run the risk of actually making your registry corrupt and bricking your windows install.
Microsoft actually used to have a registry cleaner built into windows back in the days, but removed it since it caused more problems, than it solved, since people had over 10MB of hard drive space and 2MB of RAM.