Sophos have replied with following request:
1) Access the following folder: C:\Windows\System32\drivers\
2) Rename hmpalert.sys to hmpalert.orig
3) Reboot the computer.
4) Test the issue and share result
5) Revert the changes
1) Access the following folder: C:\Windows\System32\
2) Rename hmpalert.dll to hmpalert.orig
3) Access the following folder:C:\Windows\SysWOW64\
4) Rename hmpalert.dll to hmpalert.orig
5) Reboot the computer
6) Test the issue and share result
7) Revert the changes
1) Access the following folder: C:\Windows\System32\drivers\
2) Rename savonaccess.sys to savonaccess.orig
3) Reboot the computer.
4) Test the issue and share result
5) Revert the changes
Unfortunately, the crashes can go hours between occurences so thats a lot of reboots and waiting.