Mark Schroeder,
Before I switched to an SSD SYS: drive and moved my "Documents", "Downloads", "Music", "Pictures", and "Videos" folders to the reformatted HD that was formerly my SYS drive, I routinely caught WaasMedic cruising through all the files in those folders. I have years of built-up files in those folders, including over 10,000 high-res (mostly RAW+JPEG pairs) digital camera pictures. So often I had times when it was up to 40 minutes before I could get the system responsive enough to get Task Manager and Resource Monitor opened. And by that time WaasMedic was no longer opening Microslog files - it was reading ALL the files in my user directories!
Since using File Explorer->This PC-><folder> rt-click Properties, Location tab to move these personal content folders to a different physical drive, WaasMedic does not seem to access them. (Whether or not this works if you move them to a new partition/volume on the same physical drive with the SYS: partition, I have not tested and am too lazy to test at this point.)
Regarding the folders you reference, if you rt-click-Properties on the SYS drive in File Explorer, and select "Disk Cleanup" on the General tab, then "Clean up syste files" button, select "Windows Update log files" and "OK", the cleanup process deletes all but the most recent of the folders you have identified. It is possible that if you repeat the process, it will delete the latest folder as well, but I have not tested that.
Also, you can't take the "amd64" label literally I don't believe. Since this designator first came up, I have found files (drivers mostly) for 64-bit Intel use in those directories. There are also sub-dirs in those folders with "wow64_..." names that I think are generic 64-bit files that are independent of CPU architecture concerns. I believe this is a legacy of Microsloth laziness that simply began tossing both hardware dependent and independent 64-bit stuff in "amd64" labeled locations after AMD had been the first to bring 64-bit architecture to market during a period where there was an active workstation speed/power war going on. Once demand for Intel 64-bit products hit a tipping point, rather than create a separate set of "x64" folders that would carry many duplicates of what was already in the "amd64" folders, Mocrosloth just tossed all the 64-bit stuff in the "amd64" folders. I could be wrong, but I do believe this is the case. PERHAPS MICROSLOTH WILL AT LEAST CLARIFY THIS POINT SO WE DON'T DELETE SOMETHING THAT MAY BE ESSENTIAL FOR RECOVERY PURPOSES. (Caps for emphasis that hopefully Microsloth or someone who knows for sure will clarify the "amd64" naming convention usage.)