OK, I am not going through 6 pages on this, but here is what I tried and it worked.
On my company's drive I had two folders that I could not get rid of because of Thumbs.db. I have no real Admin rights, so some of the solutions given were not available.
I tried renaming it, and I could, but I still could not delete it.
What DID work was taking the directory, right-click dragging it over to my desktop and selecting "move". I then selected it (I did not open it) and I was able to delete it.
One note, however. I did rename it before moving, so I don't know if that is needed or not.
This is similar to trying to detach attachments in mail, but the saved mail is still large. If I remember it correctly, save the mail to desktop, remove the attachments, save again, change the name and then "save as" somewhere else.
I would have to go through the permutations of that to see if renaming it AND saving as are both needed, but this has worked to bring some 20M mailings down to a few KB.